OCEAN HEALTH
René Quinton - a true pioneer in Ocean Sciences - and there are others in our pages.
   
Preamble:
 
This page deals with Tuberculosis and Isotonic Seawater as a cure.
 
Tuberculosis is a contagious disease caused by the bacterium Mycobacterium tuberculosis, identified by Robert KOCH in 1882. Also known as TB and consumption, the disease primarily affects the lungs, although the intestines, joints, and other parts of the body may also become infected. It is spread mainly by inhalation, occasionally by ingestion through contaminated foods (e.g., unpasteurized milk) and utensils. Symptoms as the disease progresses include fever, weakness, loss of appetite, and, in the pulmonary form, cough and sputum. The incidence of tuberculosis - once affecting millions - greatly decreased in many developed countries with improved sanitation and working conditions, early detection through X-rays and skin tests, and anti-tuberculosis drugs, but in the late 1980s the number of cases began to rise, particularly among AIDS patients, the poor, prison populations, and immigrants from developing countries. Another troubling development is now the spread of drug-resistant strains of the disease. This complicates reliable treatment.
This situation seems to get worse year after year. Seeing the favorable results that were obtained by Dr. Simon as described here, would it not be wise to consider seawater (Ocean Plasma) at least as a viable alternative to doubtful drugs and see it become a more health-supporting and health-promoting method of treatment?
 
Global Thread - TB 
 
 
SEAWATER - INJECTED SUBCUTANEOUSLY IN THE TREATMENT OF PULMONARY TUBERCULOSIS.
 
by: Dr. ROBERT-SIMON ET RENÉ QUINTON
 
PARIS
ÉDITIONS DE LA REVUE DES IDÉES
7, RUE DU VINQT-NEUF JUILLET 7
-----
1906
 
Translated from the French by the Ocean Plasma Team
 
 

   
Summary:
 
Select a subject ...
III. Case Results (19 cases)
 

   
I. Research conditions
 
The personal work that follows deals with nineteen patients with pulmonary tuberculosis, treated with subcutaneous Marine Plasma injections. i.e. isotonic seawater. The essence of our research results is described as follows:
 
The nineteen cases that we show here are not more or less favorable ones, chosen among others, but the only ones we were available to us to observe;
 
No subject selection was done for the purpose of this study. The nineteen tubercular patients whose case history follows were the only ones that chance presented to us (1);
 
The results that were obtained were largely attributable to the subcutaneously injected Marine Treatment, and not due to any other active treatment that could have been administered concurrently. This is particularly remarkable inasmuch as the most potent remedial processes that are available to tubercular patients today (1906) are:
 
  • selective or over-feeding,
  • extensive aeration, near the mountains or the ocean (climatotherapy),
  • physical and moral rest:
 
(1) We could have implemented the Marine Treatment on a larger scale by concerning ourselves with hospital patients; but it was an anterior event that made this impossible. (see QUINTON, l'Eau de mer milieu organique, 1904, p. 466: «I only experimented with tuberculosis in its most advanced hospitalized stages. Hospitals deal with only the most unfavorable treatment conditions for this condition: insufficient nutritional quality, inconvenient promiscuity, nightly problems, compulsory waking at first light, etc.. I would certainly recommend to any practitioner who desires to try the Marine Treatment for this affliction (injections with isotonic seawater) to not only do this in a hospital environment but also in a city environment…»)
 
a) None of our patients followed a special dietetic regimen; all were told to allow their appetite to regulate their food intake, without ever forcing them. — Better yet, among nineteen patients, eight, and five in particular (Observations IV, VII, VIII, XIII, XIX),
were not able, because of their reduced resources, to adequately nourish themselves 
quantitatively and qualitatively.
 
b) Among our nineteen patients, seventeen never left Paris for the entire duration of their treatment; therefore, no climatic action could have influenced them; aeration, being insufficient due to their stay in the city of Paris, was completely deficient in nine cases (narrow or insalubrious lodgings, work in stores, factories, etc.: observations IV, V, VII, VIII, XII, XIII, XVI, XVII, XIX). Only two of our patients spent part of their treatment away from Paris, one of whom in the country in the Sarthe (Observation 1) for 70 out of 112 treatment days, — the other (Observation XVI) in the Alps, on his own, for  153 out of 223 days. Even with these two patients, the action of the subcutaneous Marine Treatment had clearly revealed itself before their departure out of town and the addition of the climatic factor. 
 
c) Of our nineteen patients, ten continued to live, during the entire course of the treatment, the mundane existence of Paris life. Eight even had to work excessively (Observations IV, V, VI, VII, VIII, IX, XIII, XV). The additional resting cure was therefore not a factor by any of these seventeen Paris patients. With only one patient (Observation XVI, already cited) this rest cure was accomplished, in part, by forced bed rest in Paris due to weakness and subsequent easy chair cure in the Alps for two months.
 
d) Finally, out of nineteen patients, seventeen received no other medication than the Marine Method medication. Only two other subjects received other medication such as tracheal injections of eucalyptus oil and subcutaneous cacodylate of gaiacol injections respectively. Even among one of these (Observation XVI), the Marine Plasma injections resulted in early weight gain while under the preceding medication, the weight and general health state had remained stationary since two months.
 
Summarizing, the subcutaneous Marine Treatment was the only one for sixteen of our nineteen patients. Four of these sixteen cases were malnourished, badly aerated and overworked all at the same time (IV, VII, VIII, XIII). Three others, quite well nourished and aerated (but living in Paris), suffered under excessive work; an eighth languished under poor aeration and the same abuse of overwork (V); a ninth of very insufficient nutrition and aeration (XIX).
 
The seven others, well nourished but not overfed, lived the existence of a mundane and unhygienic Paris life, without real aeration and without any proper rest. We can see that with the great majority of our subjects, no other outside element came to the assistance of the effects that our subcutaneous Marine Plasma injections accomplished. For these injections to succeed, the conditions under which they were applied were really quite unfavorable.
 

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II. — Method and Technique of Injections
 
In the detailed patient observations, you will find, for each patient, the number of marine [isotonic seawater or Ocean Plasma or Marine Plasma] injections that were administered, the dosages and the injection intervals.  Generally speaking, the first injection(s) for an adult has (have) been 50 cc., and the following 100 cc. We only increased the dosage to 200 and 300 cc when 100 cc proved to be insufficiently active.
 
The injection intervals, unless influenced by patient irregularities, have invariably been from three to four days.
 
The treatment duration have been quite varied: from 23 to 133 days for primary stage tubercular patients, from 37 to 221 days for secondary ones and from 33 to 319 days for tertiary tubercular patients. At any rate, the 35 day treatment duration for a certain tertiary tubercular patient would have been deemed insufficient.
 
The seawater that we used [1906] was harvested far out in the ocean, by the competent services of the Arcachon Biological Station, reduced to isotonicity by the addition of very pure spring water, then cold-sterilized with a Chamberland filter that excluded all contact with metal or rubber, and used within three weeks of harvest.
 
The prescribed Method, demands specific protocols if the process of injecting is to be efficacious as well painless. We provide this herewith, and it has become the result of a whole year's experience.
 
(1) Site of injection. — With tubercular patients, the injection should invariably be done at the rear of the trochanterian region (lower hip region), not very deep, in the soft conjunctive tissue. One must never inject in the muscular mass of the thighs where the injection would be painful, and neither in the subcutaneous tissue of the abdominal region where the efforts of coughing would provoke a painful sensation in the early treatment days.
 
To avoid this element of pain, the first injection should never be more than 50 cc.; all others would be performed around the same location in order, once it has been done, to profit from the distension of the tissue. Complete sterility of the skin, syringe assembly should naturally be maintained.
 
Doses. — 50 cc. at most, as we just said, for the first injection. — 100 cc. right away at the second and the following injections. — If, after the fourth injection there is very little progress, with an improvement of the general state, re-appearance of appetite, reduction in coughing and expectoration, etc., then the doses should be extended to 200 cc., and, if necessary, to 300. — Any hyper-acute reaction within twelve hours following an injection would indicate that the optimum dose had not only been reached, but surpassed.
In practice, the 100 cc. dose is sufficient for adults and most other cases. The 200 cc. dose needs rarely to be increased.
 
Interval. — The interval between injections, whether 50, 100, 200 or 300 cc., should be three or fours days between injections.
 
Duration. — The duration of the treatment depends uniquely on the improvements that is obtained. A treatment should never be less than a month or a month and a half (ten to fifteen injections). It can be prolonged indefinitely without any inconvenience. — The way to proceed, in our opinion, would be as follows: after a series of twenty injections, for example, the subject should be left alone, but should be closely followed and observed, to check his weight. If the situation worsens, a new series of injections is undertaken. — In quite advanced cases of tuberculosis, second and third degree) it seems to us that the duration of each treatment should be longer. But this is for a future trial to establish with any degree of certainty.
 
Moment of injection. — The time of injection is of no consequence. It can precede, accompany or follow a meal, and neither are menstrual periods a contra-indication. This presents no inconvenience and should never be a deterrent or cause for treatment interruption.
 
Recency of injectable seawater. — Isotonic injectable seawater should be of recent origin. As we mentioned above, we have never used a marine liquid that was older than three weeks.
 
Reaction to individual injections. — The first 30 cc. injection, followed by a 100 cc injection, provokes a very weak or imperceptible reaction. Nevertheless, the patient can experience, within 24 hours following the injection, certain chills, agitation, insomnia and even a little fever. This should be of no concern. Not only will everything soon normalize, but benefits will follow. Those practitioners who are fearful of Marine Plasma injections in the treatment of pulmonary tuberculosis, because of a certain feverish reaction that an injection could temporarily provoke, are victims of a theoretical idea that, as our work shows, has no basis in reality.
 

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III. — Case Results
 
The spread of our nineteen pulmonary tuberculosis patients was as follows (1):
 
Pulmonary Tuberculosis cases...
 
  • First stage: 9 cases
  • Second stage: 5 cases
  • Third Stage: 5 cases
 
The effects produced by the subcutaneous injection treatments with Marine Plasma were as follows:
 
Effects on the general state of health.
 
Before the start of the Marine treatment, the appetite with our nineteen subjects was as follows: Absent in two cases (IV, XIX), bad in twelve cases, sufficient or good in five cases (V, IX, X, XI, XVII).
 
Following the second or third injection (six cases: I, II, VII, XII,XIII, XVIII) or around the sixth injection, at the latest (all the other cases), (2), the appetite awakened or increased; in six cases (IV, VII, VIII, XI, XIII, XVI), it became literally raging hunger. Not only was their inveterate disgust for food replaced by pleasure [for food], but an urgent need for food seized the sick...
 
(1) This case spread did not appeal to us. We mention it here as part of the primary tuberculosis cases of our patients, already carriers of small foci of humid wheezing (IV, VII), and these could have been counted as part of the secondary tuberculosis cases.
 
(2)   Except one: XVII, but where appetite was good.
 
…even outside meal times. — After cessation of treatment, and at least for several months, this excellent appetite maintained itself for all patients, except one: XIX (1).
 
Before the start of the treatment, the spread regarding sleep patterns was as follows: very bad or bad in twelve cases (with agitation and bad dreams at night), quite good in seven other cases. — From the second or third injection on, in six cases, and from the fifth injection on, in all other cases, except two, (X, XVIII), we see the agitation
and bad dreams diminish; rest becomes possible, with deep and regenerating sleep. —  After stopping the injections and at least several months thereafter, we see this sleep improvement persist in all of our subjects, except two: (XII, et XIX already cited).
 
With seven of our subjects (III, IV, VIII, X, XIII, XVIII, XIX), sleep was accompanied with «Night Sweats». Except in one case (XVIII), these symptoms diminished after the first or the third injection, and finally disappeared just about completely. — After cessation of treatment and at least for several months thereafter, improvements manifested in all cases, except one (XIX), already mentioned.
 
 Before the beginning of the treatment, the distribution of strength and asthenia (weakness) was: profound asthenia (ten cases); less or not very pronounced (nine cases). — Right after the second or fourth injection (seven cases: I, II, III, VII, XII, XIII, XIX), or a little later (all other cases except one: XVIII), strength returned; the voice, gestures changed, joyfulness, euphoria appear; the demeanor of the patient is transformed. — After cessation of treatment, and at least several months thereafter, this improvement persists with all subjects, except one (XIX), already mentioned.
 
 The withered skin tone, sallow, waxen, the reddish blotches (freckles or ephelides), lifelessness of the look, of the flesh, the wrinkles, all these various attributes that all patients exhibited, were replaced, in a few weeks, with all our primary and secondary tubercular patients, with two of our tertiary tubercular patients (of five), by a clear and rosy skin tone, uniform and smooth, with alert eyes, firm and invigorated flesh, and all that rendered certain patients almost unrecognizable (I, VII). — After cessation of the injections, and for at least several months thereafter, these improvements persisted in all subjects.
 
Before the start of the treatment, two of our patients (VI, IX) suffered from pronounced constipation, another (XV) vomited daily after coughing in the morning; another (XVIII) had diarrhea and vomited food; five had persistent headaches (V, VI, VIII, IX, X); two trembles just about constantly (I, VI). — Under the influence of the injections, and after various time intervals, the constipation, morning vomiting, headaches, and trembling disappeared more or less completely. Only the food vomiting and diarrhea of the tertiary case XVIII had temporary improvement. — After cessation of the injections, and for at least several months thereafter, these improvements persisted in all subjects.
 
(1)  This subject was really insufficiently treated for his advanced condition (seven injections, tertiary tuberculosis).
 
Effects on the gynecological condition (1).
 
Seven of our subjects (I, III, VIII, XI, XV, XVI, XVIII) exhibited dysmenorrhoea (painful menstruation) and three had menstrual migraines, four had abundant leucorrhoea (menstrual bleeding), three with persistent headaches, two with [menstrual] retardation, and one with constipation. — In six cases, following the Marine Treatment, the dysmenorrhoea receded or disappeared at the first menstrual period following the injection; in two these cases, this condition reappeared at following menstruations. The three menstrual migraine cases normalized completely (III, XV, XVI); there was total normalization of the three persistent headache cases in one case (IX), and notable improvement in the two other cases (VIII, XV); the constipation disappeared (IX); the suspended periods with one subject returned (XV); the leucorrhoea losses resolved completely (I), another was improved (IX), and the last two were stationary (VIII, XI). — After the injections stopped, and at least during several months thereafter, these improvements persisted.
 
(1) We decided to refer to the gynecological condition with the three following symptoms, so frequently associated with the menses that they seem to constitute a sort of morbid entity: Menstrual problems with dysmenorrhoea, migraines and headaches, and constipation, (see Robert Simon et Quinton, Soc. de Thérap., 24 January 1906).
 
Effects on Patient's Weight
 
The importance of the WEIGHT factor in pulmonary tubercular patients is absolute.
Before the start of the treatments, all our subjects, except two — one in the primary stage, stationary (III) and the other in the tertiary stage, worsening (XVI) — lost weight. This loss of weight was from 2 gr. to 33 gr. average per day with tubercular patients in the primary stage, from 4 gr. 1 to 86 gr. in the secondary stage and from 4 gr. 3 to 80 gr. 6 in the tertiary tubercular stage.
 
As soon as the subcutaneous Marine Treatment was instituted, the weight for the above-cited cases increased. The average increase during the treatment period was 2 gr. 2 to 96 gr. 8 per day for primary tubercular cases, from 2 gr. to 28 gr. 4 with secondary tubercular cases, except one case where the patient continued to lose (6 gr 9 per day); and from 29 gr 6 to 38 gr. 1 with two tertiary tubercular cases (out of five), the others continued their [weight] decline but even that was slowed.
 
This 'weight' benefit is not limited to the treatment period but continued to manifest itself for months (two to eight) after treatment stoppage in most cases: in seven out of nine in the primary stage (4 gr. 3 to 28 gr. 3 per day), three out of four secondary cases (2 to 14 gr. 7), one out of three in the tertiary stage (25 gr.) and this is eleven out of sixteen cases. The average weight tendencies, before, during and after the injections of Marine Plasma, in each of the three tubercular categories and collectively, are summarized in the table shown below.
 
Cliquez pour voir l’image plus grand
 
English explanations (from left to right):
 
Column 1: Degree of Tuberculosis - 1st, 2nd and 3rd stage- General Average as total
Column 2: Before start of treatment - No. of days of observation & weight loss per day per subject
Column 3: Weight picture during treatment (No. of days and weight loss per day/patient)
Column 4: Weight picture after treatment stopped - same criteria as above
 
 
One can readily see that the weight loss of 9 gr. 4 per day and per subject, recorded before the start of any Marine Plasma injections, was transformed into a weight gain of 13 gr. 7 during the injection period and 5 gr. 1 after such treatment stopped — and this average figure is based on 9343 days of experience, 5237 before the Marine Method Treatment and 2097 during such treatment and 2011 thereafter.
 
The same numbers, calculated not only per day but per month, would give:
 
Weight loss per month and per subject, before Marine Treatment: -282 gr.
Weight gain per month and per subject, during Marine Treatment: +411 gr.
Weight gain per month and per subject, after Marine Treatment: +153 gr.
 
This table and graphs shown below disclose the average weight situation per pulmonary tuberculosis stage and per subject - before, during and after the Marine injection therapy.
 
 
Note:
Premier degré = primary stage
Deuxième degré = secondary stage
Troisième degré = tertiary stage of pulmonary tuberculosis
 
Effects [of Marine injections] on the pulmonary condition.
 
Before the start of the Marine Treatment, five of our patients had a moderate cough, four had frequent coughs, nine were coughing stubbornly. The expectoration, weak in eleven cases, were abundant in the eight others. — In a third of all the cases, from the first injection on, except for three of the tertiary stage, the coughing and expectoration experienced a 50% reduction and then slowly disappeared. — After cessation of the treatment and at least for several months thereafter, this diminution or this disappearance [of coughing] persisted in all cases except one (XIV).
 
In seven cases where dyspnea (air hunger or shortness of breath) was present, four improved very notably (one in the primary stage, three in the secondary stage) and remained improved for several months after stopping the injections. Three dyspnea cases of the tertiary stage did not have any results (XVII, XVIII, XIX).
 
 
Fig. 1. — Graphic illustration showing the loss or gain of weight, for primary stage tubercular tuberculosis patients, calculated per day, before, during and after the hypodermic Marine treatment.
------------- = before
________ = during
._._._._._. = after
 
For all nineteen subjects, thirteen exhibited no hemoptysis (spitting up of blood). No hemoptysis had been observed either during or after the Marine treatment. The other six had previously experienced occurences of hemoptysis: the first, one, two weeks before the start of the injection treatments (V); the second, three, thirteen or fourteen years previously (XII); The third, an indeterminate number of times since several months (XIII);  the fourth, two, since three years (XV); the fifth, three, since four months (XVI); and the sixth, eighteen, since four years (XVII).
 
 
Fig. 2. — Graphic illustration showing the loss or gain of weight, for secondary stage tubercular tuberculosis patients, calculated per day, before, during and after the hypodermic Marine treatment.
------------- = before
________ = during
._._._._._. = after
 
Four of these patients exhibited no new bloody expectorations during the Marine treatment. The two others saw their hemoptysis greatly diminish; for one (XII) they became less frequent and less abundant at the same time; and with the other, (XVII), figure IV, (below), established by the patient, shows a striking improvement, coincidental with the Marine Plasma injections. With this subject, the hemoptysis incidences, present since four years, had not stopped to become more abundant.
 
 
Fig. 3. — Graphic illustration showing the loss or gain of weight, for tertiary stage tubercular tuberculosis patients, calculated per day, before, during and after the hypodermic Marine treatment.
------------- = before
________ = during
._._._._._. = after
 
They had started in 1904 with such abundance that a terminal hemoptysis was always feared. Then, during the ten and a half months of Marine treatment, the most abundant hemoptysis was three mouthfuls of blood, the others being only one mouthful, or only several tinted expectorations. Since this patient received a 300 cc. isotonic seawater injection every four days, one can see that the fear that subcutaneous injections could cause high blood pressure problems with hemoptysis patients is practically unfounded (1). Never in our experience have seawater injections provoked hemoptysis; these only improved the [adverse] symptoms of hemoptysis.
 
 
Note:
Crachats simplement teintés = simply tinted expectorations
Sang pur = pure blood
Avant le plasma marin = before Marine Plasma
Pendant le plasma Marin = during Marine Plasma
 
After the treatments were stopped, two of our hemoptysis patients (two women, XV, and XVI) had simply once, and during their menses, several colored expectorations and one hemoptysis event respectively.
 
(1) Look up the discussions regarding this subjects by LAUFER,  ROBERT SIMON, Soc. de  Thrap.,
28 February, 14 March, 28 March 1906.
 
In certain lung areas, our first stage pulmonary tubercular patients had certain manifestations before the start of the treatments, such as: seven had outpouring of liquids (matity); nine had pulmonary rubbing (frottement); four had dry wheezing; two had a small focus of humid wheezing. — At the end of the subcutaneous Marine treatment, the outpouring, the spasmodic breathing had of course not varied or at least just a little; but in seven cases (out of nine), the vesicular murmur was not only more perceptible but also stronger; the rubbings, the dry wheezing, the humid wheezing had disappeared. — Several months after the cessation of the treatment, not only did the disappearance of these last symptoms last but the vesicular murmur had become stronger and had a more extensive spread in three cases.
 
The turbercular secondary stage cases exhibited (1): four, outpouring of liquids (that for one case went to complete obscurity of one lung); one, rubbing; two, [labored] breathing; three, rubbing, dry wheezing; four, humid groaning. — At the end of the Marine treatment, the outpouring of liquids, the rubbing, the dry wheezing had not changed or not much anyway; but in two cases (of four), the vesicular murmur had strongly increased; one could see its progressive reappearance in the previously completely obscured lung; no rubbing persisted; in two cases the humid groaning had improve in an encouraging way; and in two other cases they had completely disappeared. — With the only subject in this category that was observed after the cessation of the Marine treatment (X), the improvement, i.e. the disappearance of the pleural rubbings and the humid groaning never returned after eight months [of monitoring].
The tertiary pulmonary tubercular cases exhibited: five, outpourings of liquid; five, of
deep labored breathing; une, wheezing; four, rubbing; four humid humid groaning; four, gurgling. — At the end of the Marine treatment, two foci of rubbing (or four) had disappeared; two caverns seemed dried out (disappearance of wheezing and of gurgling), and the three others had seemingly not been influenced by anything during the treatment (persistence of the wheezing and gurgling).
Finally, take notice that, in two cases, one of the primary stage (IV), while extremely improved, the secondary stage other (XIV), the rubbings that had not existed at the beginning, could now be heard.
 
Effects on fever:
 
Only two of our patients took their temperature before the treatments and took it during the treatment. The social condition of most of the others, and the working conditions under which they labored, did not permit them any thermometric measurements. Therefore, this part of our documentation is insufficiently documented. Nevertheless:
 
Nine of our patients were, by all appearances, apyretic, i.e. had no temperature, (I, II, V, VI, VII, IX, XI, XII, XIV). — They remained this way during the whole treatment and thereafter.
 
(1) We do not understand, in this nomenclature, the case of laryngeal tuberculosis
 
Four others (III, VIII, X, XIII), without fever during the day, had night sweats, probably due to the feverish night activities, highlighted by Barbier (1). — These sweats diminished and then completely disappeared under the influence of the Marine injections.
 
The six last patients were composed of one sub-feverish (XVII), four intermittently feverish (IV, XV, XVI, XIX), and une chronically feverish patient (XVIII).
The temperature of the sub-febrile, taken daily since four years at 3:00 pm, was, on the average, adjusting for the periods of pulmonary bleeding:
 
The temperature of the sub-febrile patients (those with low average body temperature), taken daily since four years at 3:00 pm, had on the average, and allowing for periods of
hemoptysis (coughing or spitting up of blood from the respiratory tract): 37°5 (1901), 37°8 (1902), 37°5 à 38° (1903), 38°5 à 37° (1904), 37°2 à 37°4 (January-February 1903). During the six months and a half of Marine Treatment, the temperature, taken at the same time, oscillated constantly between 36°7 and 37°3, with adjustments having been made for minimal reactionary temperature reactions on injection days. This was really quite slight, almost always less than 37°5, reaching 38° only three times.
 
During the treatment and thereafter, the four patients with intermittent elevated temperature witnessed their temperature rise or failed to notice it. This then became more intermittent and finally disappeared altogether.
 
(1) BARBIER, Thermometric Research on Tuberculosis. Soc. méd. des Hôp., 10 November 1899, p. 844, — in Traité de médecine by Bouchard and Brissaud, 2nd edition., 1901, Volume VII, p. 203 Paris, Massn. 
 

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IV. — Summary of obtained results - Interpretations
 
The obtained results can briefly be summarized as follows...
 
With all tubercular patients that had been treated, almost without exception, —
we witnessed rapid improvement, more progressive and persistent appetite, better sleep patterns, the habitus (the physical and constitutional characteristics of an individual, especially as related to the tendency to develop a certain disease) and the entire general state of health.
 
With all tubercular patients that had been treated, except four (one in the secondary stage, three in the tertiary stage) — the immediate and progressive weight gain for several months (two to eight), in 77% of all cases, after the cessation of treatment.
 
Amelioration of pulmonary lesions, practically completely healed in all primary stage patients, — quite remarkably in four of five secondary stage patients and notable with two of five patients in their tertiary tubercular stage. We saw persistence of this improvement during several months (two to eight) after the termination of the injection treatments.
 
We also saw an anti-thermal action that was probably due to the treatment and, in all cases, absolutely innocuous (without adverse effects). While a perusal of these results should stir interest, a comparison will highlight them here. 
 
We know that among all the French Ocean clinics, the Arcachon was the most famous one for marine climate treatment of pulmonary tuberculosis. In his work "Cure marine de la phtisie pulmonaire (1897)" (Marine cure of the phthisis of pulmonary tuberculosis (1897) - This means: a disease characterized by the wasting away or atrophy of the body or a part of the body. Old definition of 'Tuberculosis of the lungs'. No longer in scientific use one hundred years later), Lalesque reports in detail on about sixty patients, treated by him at Arcachon and chosen among many others in his practice of many years.
Let's complete the selection dealt with by this author and let's delete from his detailed observations all those that had diminishing weight. We obtain this graph.
 
 
 
Note:
First column - Total # of treated cases by Lalesque
Second column - # of cases chosen and reported on by Lalesque
Third column - # of days of treatment
Fourth column - Average weight gain per day and per patient - Average for all subjects
 
Let's conduct the same operation for our own work, i.e. let's eliminate the four observations where there is weight loss:
 
Number of cases treated by us:
Number of selected cases:
Number of treatment cases:
Average weight gain per day per subject: 
19
15
1555
24 gr. 3
 
In this way, at Arcachon, under the influence of the three orthodox cures: climatic, dietetic and rest, for 41 subjects, especially chosen among 213, the average weight gain was 29 gr. 9 per day and per patient, those who were relatively well off and at ease.
 
In Paris, without a cure, either dietetic, or climatic, or rest cure - for 15 patient out of 19, of whom four of those fifteen were mal-nourished, seven were badly aerated, eight were subjected to excessive work - the average weight gain under the influence of the subcutaneous marine cure was 24 gr. 4.
 
The weight gain benefit somehow summarizes, by itself, the benefit that was seen with all the other available cures since in our observations - affected in the most unfavorable hygienic and dietetic conditions - our treatment is equivalent to the benefit obtained by the most powerful classical treatments at Arcachon as well as all the natural resources that made this clinic so famous. Therefore, it seems that with the subcutaneous Marine Plasma injections maybe we possess a new treatment that is ideal and of utmost value for pulmonary tuberculosis.
 

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V. — The Work of other Authors
 
The research of other authors regarding this same question - works done by Pagano (1), Mathieu (2), Fournel (3), L. G. Simon et Pater (4), Lalesque (5), Védy (6) — will enable us to enlarge upon our conclusions.
 
Let us, first of all, divide these researches into two groups: a first group, composed of
those whose work was according to our method or a similar one; and a second that involved all the others.
   
 Works of  Pagano, Mathieu, Fournel, Lalesque, carried out according to our method or a similar one. 
 
These works confirm purely and simply our own work regarding the action of subcutaneous Marine Plasma [Ocean Plasma] Injections in the case of pulmonary tuberculosis regarding the awakening of the appetite, return of normal sleep, the improvement of the general state of health, reduction of coughing, spitting and nocturnal sweats, stethoscopic signs such as disappearance of wheezing, etc., etc. The concordance is so obvious that it is useless to further elaborate on this, except one point that our research has sufficiently illuminated: the febrile (fever) reaction where Pagano and Lalesque bring their contribution, namely where two feverish patients, one of whom at 38°, the other at 38°3, and whose temperature diminished to 37°2-37°3 for the first (Pagano) and to 37°7 for the second patient (Lalesque).
 
(1) PAGANO, Rivista critica di clin. med., 1904, Volume V, n" 51.
(2) MATHIEU, Progrès médical, 31 December 1904, ps. 523-524.
(3) FOURNEL, Académie de médecine, 23 May 1905, and excerpts.
(4) L. G. SIMON et PATER, Presse médicale, 19 August 1905.
(5) LALESQUE, Journal de méd, de Bordeaux, 24 September 1905, p. 688.
(6) VÉDY, Thèse, Bordeaux, 3 janvier 1906. L’eau de mer en thérapeutique et principalement chez les tuberculeux, 1 vol. 99 pages, Imprimerie commerciale et industrielle, Bordeaux, 1906.
 
But now we have come to the one essential effect or action that synthesizes all the others, namely the weight effect.
 
In the following table, we provide, for each experiment done by the various authors:
 
  • the pathological state of the patient,
  • the average amount of isotonic seawater injected per day (1),
  • the duration of the treatment in days (1),
  • the duration of patient observation (in days) after cessation of treatment,
  • the weight gain per day for each patient - during and after the treatment.
 
What is particularly evident when one studies this table is the superiority of a certain number of results, notably those of Lalesque, as compared to ours. As a matter of fact, while our strongest weight gain during the subcutaneous injection treatment was 96 gr. 8 per day, Lalesque reports three observations where these daily weight gains are: 100 gr., 111 gr. 8, 129 gr. 4. Furthermore, while our strongest [reported] weight gain for the period posterior to the treatment is 28 gr. 3, Lalesque reports for this period daily weight gains of 57 gr 5 and 71 gr. 2. per day.
 
Our results are therefore not only confirmed but they are surpassed.
 
(1) Let us remember that, for adults, our method is: give injections of 100 to 200 cc. of isotonic seawater, every three or four days, for at least one month and a half. This is from 30 to 50 cc per day.
   
Works by L.-G. Simon et Pater, Védy, Cariés, Mongour, carried out as per a method different from ours...
 
  • L.-G. Simon et Pater (Presse médicale, 19 August 1905) experimented with Marine injections in pulmonary tuberculosis of children between two and fourteen years old. Their results have been NIL.
     
When we study their observations, we see the cause. These authors injected their subjects with doses that were from 10 to 33 times too insufficient. The graph shown below (fig. 5) represents the doses of isotonic seawater, per day and per kilogram of a child's weight, as used by the different authors during the infantile treatment. One can see the insufficiency of these injected doses by Mr. L.G. Simon et Pater.
 
Fig. 5. - Graph indicating the Marine Plasma injection dosages, with treatments involving children, by different authors. ---  Evident insufficiency of dosages injected by Mr. L.G. Simon et Pater.
   
  • Védy, Carles Mongour (in Thesis Védy, ps. 32-57, 68-82) report on nineteen observations, adopted method, impossible to classify. In two of these, seawater was administered orally; in seven other cases, the injections were discontinued after eight days; in four cases, the daily doses did not exceed 3 gr. 5, 4 gr. 4, gr. 7, 6 gr. 5 (instead of 30 to 50 gr., according to our method); one other (Mongour) is mute regarding the results - and with fourteen observations, only four are favorable.
 
The doses, the duration of the treatment, the weight gain regarding the remaining five observations are as follows:
 
AVERAGE DOSE
per day (gr)
NUMBER OF DAYS of treatment
WEIGHT GAIN 
per day (gr)
 
RESULTS
14
17
-61.7
Disappearance of wheezing
10
70
+122.4
Disappearance of moist wheezing
20
12
?
Disappearance of moist wheezing and fever
12.7
31
0
3rd stage - no improvement
22.2
22
+46.1
?
 
The weight loss of 61 gr. 7 per day refers to one patient who had previously lost 63 gr.
 
One can see in these observations, where an adopted method comes closer to ours (as far as injected doses and duration of treatment are concerned), then the results become
quickly more favorable. The disappearance of dry wheezing, humid wheezing and fever becomes reality. Even the non-improvement of one tertiary case conforms to our results.
 
The works of all these authors can be summarized as follows:
 
  • Identical or superior results to ours in cases where our indicated method was followed;
 
  • Results were nil or inconsistent in cases where a method was used that was very different [from ours].
 
Interpretation
 
The absent or inconsistent results were easy to discern; they were the result of an erroneous method that was best abandoned.
 
The identical results to ours can also be easily discerned; they confirm the effectiveness of the Marine Method.
 
The superior results, obtained by Lalesque, seem to have had a very simple cause that he succeeded in unraveling, and that is: while we conducted our experimentation in often very poor hygienic and dietary conditions, this author operated with the help of climate, a good regimen [diet] and rest.
 

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VI.— General Conclusions
 
This work brings to light four principal facts:
 
The remarkable action of Marine Plasma [Ocean Plasma], via subcutaneous injection, in the case of pulmonary tuberculosis, — an action that, despite any adjunctive treatment and in unfavorable hygienic and dietetic conditions, permits a re-establishment of the general health state, the awakening of the digestive state, weight gain and the regression of pulmonary lesions;
 
The complete harmlessness of the treatment;
 
Its absence of activity or its inconsistency outside of a defined method;
 
The possible advantages that might result when today's (1906) classical cures are added to the Method such as proper diet, rest, aeration and climate. The conclusions that we reached from the ensemble of this study are as follows:
 
  • The subcutaneous injection of isotonic seawater appears to be a new treatment for pulmonary tuberculosis that deserves attention. This treatment alone seems to be at least as powerful as the three associated cures of diet, aeration and rest. This fact by itself could be judged sufficient to practice principally in the big [city] centers and with sedentary people.
 
  • With this new therapeutic process, and in all the different pulmonary tuberculosis forms, we have seen so far no apparent contra-indications;
 
  • Its efficacy depends on its methodical application, defined in detail in this study, and which can be summarized this way: Inject about 100 cc. every three days or so, for about six weeks, with follow-up supervision and possible repeat treatment if necessary;
 
  • The climatic cure, or simply air and rest, should add even more to the benefice attributable to the subcutaneous Marine injection [of isotonic seawater or Ocean Plasma].
 

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