René Quinton - a true pioneer in Ocean Sciences - and there are others in our pages.
FOR THE USE OF Océan Plasma
(according to Rene Quinton)
The description in the following page faithfully reflects the original therapeutic protocol as it was utilized by Rene Quinton himself more than one hundred years ago.
Here is the ORIGINAL Treatment protocol (translated from the French):
« The marine treatment which we have practiced in the Parisian hospital services (St. Louis, Beaujon, Hotel-Dieu, Tenon, Maison Dubois, Pitie and the Asylum of Mouleau) consisted of injecting our seawater which we reduced to organic isotonic consistency (see notes at top of this page for full explanation), per dosage for this mixture, to one hundredth to one hundredth and a half of the body weight.
The first injections I practiced (July - August 1897) were intra-venous injections. In my absence, in a desperate case of cirrhosis, death being anticipated for that same day, a temporary intern obtained complete success after a subcutaneous injection of my preparation which he administered without any hope. The patient left the hospital on his own two weeks later.
I don't provide my formula as being final or the best one could use. I thought one had to inject the isotonic way in order to avoid unknown or troublesome factors, however I learned from physicians of the Marine Service who have had excellent results from simply injecting my preparation in its natural form. This practice would have the advantage of reducing by two thirds the volume to inject - a comparative experience would have to be tried. I limited the dosage to one hundredth or one hundredth and a half of the injection volume because it seemed to me that this dosage (same concentration as human plasma) was sufficient to produce the immediate effects of a double or triple dose, however, it is not established that a stronger dose by itself would have any advantages, which I have not had the occasion to observe.
The quality of the liquid to be injected provided more precise observations which could be summarized with finality. It no use to contemplate the composition of an artificial seawater. It must be treated according to my protocol and reduced to approximate organic isotonicity.
Minimal injection dose: This depends on the condition of the patient. Please consult the Success Cases for guidance.
Frequency of injections: When the injections must be repeated: every five days, then every six, seven, eight days etc., according to the readily discernible duration of its effects (see details further down).
Effects from the Injection(s):
When several injection are to be done on the same patient, it is best to inject at the same place. The local pain of the first injection will only be slightly felt during subsequent injections.
An injections is followed by a reaction that lasts about twelve hours. At a certain variable moment (one hour, two hours or three hours after and sometimes even while performing the injection itself if it is done slowly), the patient will feel chilly, sometime violently so, with chattering teeth and more or less intense thirst. Body temperature will rise without interruption during four or five hours (about 1.5 to 2.0 degrees C) and then will come down as it came up to finally stabilize below the initial temperature. The thirsty patient will drink 1 to 3 liters of water. He typically has absolutely no appetite, may have some nausea or slight headaches. The more this reaction is felt the more benefit will be derived from the injection. In any case, it is not to be feared with regardless of the weakness of the patient or his initial temperature. In the case of febrility, when the temperature before the injection is 39.5 degrees C, it can rise to 41.5 C and even remain for six consecutive hours at 41 degrees C without the slightest inconvenience.
Twenty-four hours after the injection, one finds the patient generally down, not only because of the crisis which just happened but also due to the resulting partial insomnia. The improvement is however evident by certain symptoms that begin to clearly show, in favorable cases, around the 36th hour or the latest on the second day. The improvements are constant and are progressive during the 3rd and 4th days. One can witness sometimes a veritable resurrection of the patient. Striking by its suddenness: all pain or uneasiness that may have been present before the injection have left; strength returns; appetite - non-existent before the treatment - becomes exaggerated with sudden hunger and the patient, bedridden for weeks, arises and walks around for several hours.
On the fifth day, in the morning - complete change. The scene is dominated by the same general weakness as prevailed before the treatment, except in acute cases where one injection suffices to produce a definite improvement. A second injection is therefore administered. The described cycle of effects occur once again but with more pronounced improvements.
The injections are spaced out in this natural manner for five, six, seven, eight days - according to the benefits that are obtained.
The difficulties which I had to face, when the Arcachon station could no longer send me the seawater that was treated according to my protocol, have successively interrupted many of my [clinical] trials. As a collective group, my preparations nevertheless seem to have proven to be a powerful adjunctive therapy.
In three particularly grave acute cases, infectious gastro-enteritis of indeterminate nature, oxalic acid poisoning, advanced liver cirrhosis, success was immediate and complete. In the case of syphilis, one early malignant syphillitis and one advanced case, the injection was followed, right from the second day, by very rapid healing of the lesions which covered the patient's body. In one case, healing was mostly complete after seven days. We obtained the same results in cutaneous tuberculosis.
The therapeutic action of seawater is therefore evident. Future trials should measure and evaluate it further. »
Rene Quinton

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